Our PhD student Jaanus is currently doing research in the group of Prof. Edwin De Pauw at the University of Liege in Belgium and he had a nice opportunity to take part in a 21st annual meeting of Belgian Society for Mass Spectrometry that was held on 29th of March in Liege. The meeting was organized in honour of Prof. Edwin De Pauw to summarize his work as he intended to retire after this year. Luckily for the mass spectrometric community, he will be actively involved in the research at least for four coming years.
Prof. Scott McLuckey opened the day with a presentation about strategies for achieving enzyme-like specificity in the gas-phase fragmentation of peptide and proteins. He showed different strategies how to cleave for example specifically at asparagine or lysine.
Prof. Andrea Sinz presented the results of the development of cleavable cross-linkers. Additionally, she pointed out that although cleavable crosslinkers are available on the market most of the groups determining the protein structures still use the noncleavable crosslinkers and do not take advantage of additional information provided by cleavable crosslinkers.
Dr. Valérie Gabelica presented the results of the studies of nucleic acid noncovalent complexes in native MS. She said that by knowing and studying the fundamentals of ESI processes one gets also a real insight into phenomena seen in different applications (in her case, nucleic acid noncovalent complexes). She also pointed out that unfortunately, scientific community publishes solely positive results which result in biased and non-universal theories.
Jaanus Liigand also had the possibility to present the results of our studies of standard substance free quantitation in LC/ESI/MS analysis and industry showed a great interest in our approach which could be beneficial for their needs (see the poster here).
It was a really nice day full of interesting presentations and discussions.