Introductory meeting of EACH Students 2015

EACH_Student_Introductory_Meeting_2015Today (Aug 31, 2015) the introductory meeting of the EACH Erasmus Mundus students with the programme coordinators took place at UT Chemicum.

All the 18 students (originating from Ukraine, China, India, Jordan, Congo, Nepal, Nigeria, Montenegro, Serbia, Macedonia, USA and Estonia), who start their studies in EACH in this autumn were participating. An overview of the programme was given (the slides are available from here) and a large number of questions were asked and answered, accompanied by tea/coffee and cake.

This is the first group of students who start their studies in the EACH Erasmus Mundus programme, so, exciting months are ahead, both for students and programme teachers/coordinators!

Photo: EACH Students and their Tutor Kaisa Tihkan (on the right).

 

MSC Euromaster Summer school 2015: Feedback from students

UT_Students_at_MSC_Euromaster_Summer_School_2015The MSC Euromaster Summer School 2015 in Pulawy (Jul 12-24, 2015) was again a success and the student feedback were very positive. Two reflections from AMS students are presented here:

Sagar Patel: I will remember my time spent in summer school held at Pulawy (Poland) for a lifetime. It was amazing and I don’t have words to express my feelings. I got very useful and practical knowledge about Metrology in Chemistry, statistics, interactions with customers, ISO 17025 and many more. Apart from studies I got a chance to work with students and professionals from different countries.

Karl Kütt: The MSC Summer school on metrology in chemistry has been a great addition to my studies. It combines the theoretical knowledge that I have learned in my program with the teamwork skills and real world problem solving skills that one encounters when running a real laboratory or a project. The course had extensive lessons on both uncertainties in chemistry and validation (a key aspect in the ISO 17025 standard). The neat thing about the summer school is that in its practical exercises you’re not presented with a wrong or a right way, but a situation in which every decision has its pros and cons. I think going to the summer school greatly improved my skills in working in a group, solving complicated problems as well as helped me make important contacts and great friends in the field of metrology.

Image on the left: UT students who participated in the MSC Summer School 2015, from left to right: Sagar Patel (India), Sylvestre Pagkeu (Cameroon), Martins Jansons (Latvia), Karl Kütt (Estonia)

MSC Euromaster Summer school 2015 in Puławy

Group_Photo_MSC_SS_2015This week saw the start (on Mon, Jul 13, 2015) of the 8th MSC Euromaster summer school 2015 in Puławy (Poland).

As in previous years, a core aim of the Summer school is shifting the activities away from the classical lecture-type of teaching by increasing the share of discussions, hands-on work, teamwork. As usual, a key activity of the summer school is the contest of student teams (setting up virtual laboratories and interacting with customers), which tests their knowledge and skills in all areas of metrology in chemistry.

This year the summer school makes further advances in terms of this “core shift”. One of the modules, which was carried out differently, was measurement uncertainty, which was the the main responsibility of UT during the summer school. Instead of the classical way – starting with lecture and then moving to discussion – the students were well in advance of the Summer school asked to learn the basic (and quite some not so basic) topics of measurement uncertainty using the web course Estimation of Measurement Uncertainty in Chemical Analysis. This way the lecturing part was omitted completely from the Summer school, as students had the necessary preparation. Thus, the whole measurement uncertainty module at the Summer school consisted of a big session of discussions and problem solving.

Another module, where hands-on work was very important was the Internal and external quality control module (delivered mainly by Ricardo Da Silva from University of Lisbon). He organised an “interlaboratory comparison” between students (in visual photometry) as a part of the session! Students were very excited to see how their results compared to their colleagues’ results.

The summer school still has one week to go and will finish on Fri, Jul 24, 2015.

 

Tutorial Review on LC-MS Method Validation

Graphical_AbstractThe LC-MS group at the UT Institute of Chemistry were recently invited by the journal Analytica Chimica Acta to write a tutorial review on the topic of validation of liquid chromatography mass spectrometry (LC-MS) methods. This work has now been completed. The tutorial review intends to give an overview of the state of the art of method validation in liquid chromatography mass spectrometry (LC–MS), especially with electrospray ionisation (LC-ESI-MS), and discuss specific issues that arise with MS (and MS-MS) detection (i.e. LC-MS-MS) in LC (as opposed to the “conventional” detectors). The review was eventually split in two parts (because of its large volume):

(as an April joke from Elsevier, part II appears page-wise before part I)

The review addresses and compares all the major validation guidelines published by international organizations: ICH, IUPAC, AOAC, FDA, EMA (EMEA), Eurachem, SANCO, NordVal, European Commission Decision 2002/657/EC. With every performance characteristic the tutorial review briefly compares the recommendations of the guidelines.

The Part I briefly introduces the principles of operation of LC–MS (emphasizing the aspects important from the validation point of view, in particular the ionization process and ionization suppression/enhancement); reviews the main validation guideline documents and discusses in detail the following performance parameters: selectivity/specificity/identity, ruggedness/robustness, limit of detection, limit of quantification, decision limit and detection capability. The Part II starts with briefly introducing the main quantitation methods and then addresses the performance related to quantification: linearity of signal, sensitivity, precision, trueness, accuracy, stability and measurement uncertainty. The last section of Part II is devoted to practical considerations in validation and a possible step by step validation plan specifically suitable for LC-MS-MS is presented.

With every method performance characteristic its essence and terminology are addressed, the current status of treating it is reviewed and recommendations are given, how to determine it, specifically in the case of LC–MS methods. In many cases the published guidelines remain too general for practicing analyst. This tutorial review gives more specific advice based on the best available practice.

Based on the recommended approaches presented in this tutorial review an LC-MS validation software ValChrom is currently under development by the UT team. The software development is supported by the EU Regional Development Fund (Development of software for validation of chromatographic methods, Project No. 3.2.1201.13-0020).