Metrology and Quality Assurance in Chemistry
Contact: Prof. Ivo Leito, ivo.leito@ut.ee
The research area of metrology and quality assurance in chemistry – involving measurement uncertainty, method validation, interlaboratory comparisons, etc – supports all our research directions where measurements or chemical analyses are involved. It is also crucially important for our teaching work – EACH Erasmus Mundus and AMS study programmes as well as two MOOC courses – Estimation of Measurement Uncertainty in Chemical Analysis and Validation of LC/MS Methods. It is also essential for functioning of the UT Testing Centre where our group is strongly involved.
Important achievements and results include:
- Tutorial review on validation of LC/MS analytical methods: Part I, Part II.
- Tutorial review on estimation of LoD of LC/MS methods: Part I, Part II.
- Massive open online course (MOOC) Estimation of Measurement Uncertainty in Chemical Analysis
- Massive open online course (MOOC) Validation of LC/MS Methods
- Development of software for chromatographic method validation: ValChrom
- Web collection of measurement uncertainty examples in analytical chemistry, including:
- Uncertainty estimations (at different level of detail) have been carried out for different measurements and analyses:
- Uncertainty computational pKa values of strong acids in water
- Uncertainty of mixed computational/experimental pKa values of strong bases in water
- Measurement uncertainty of gas-phase basicities of strong bases
- Measurement uncertainty of basicities of bases in acetonitrile
- Measurement uncertainty of quantifying mercury in particulate matter
- Measurement uncertainty of dissolved oxygen measurement, etc.
Examples of Measurement Uncertainty Budgets in Analytical Chemistry
Our group is a member of the Technical Committee of Metrology in Chemistry (TC-MC) (https://www.euramet.org/technical-committees/tc-mc).