From the 27th of August to the 2nd of September, two members of our Chair of Analytical Chemistry – Ngan and Larissa – attended the 24th International Mass Spectrometry Conference (IMSC 2022) in Maastricht, The Netherlands. They both presented their posters under section B: Instrumentation and methods. All abstracts of the posters can be found in the abstract book.
Larissa: “The topics that stood out the most to me were proteomics and metabolomics, especially in the field of single-cell analysis. Overall, the talks were very interesting because there was a huge variety in what kind of investigated samples. Besides, vendors were able to present their latest products, mainly focused on LC-MS/MS instrumentation.”
Ngan: “The conference program had so diverse topics. Personally, I loved the talk by Livia S. Eberlin – a Curt Brunnée awardee about Guiding Medical Decisions with the MasSpec Pen Technology. Different workshops were held in the end of each day, for example: FeMS (females in MS), Forensics, and Career workshops in which professors, vendors, and recruiters gave speeches to inspire students to do internship, to find balance in work-life, or to connect mentees and mentors. The first day of the IMSC 2022 conference coincidentally happened to be on my birthday which made this experience very special and memorable to me. I had a chance to open my eyes and see the world through the MS glasses.”
Larissa’s poster was about derivatization-targeted analysis, where derivatization with diethyl ethoxymethylenemalonate (DEEMM) was combined with neutral loss scan mode for the detection of amino compounds.
Ngan presented her poster about Coumarin-based derivatization reagent for LC-MS analysis of amino acids. In this study, she reported a first time synthesized fluorogenic derivatization reagent in UT lab named Coumarin151-N-succinimidyl Carbamate (Cou151DSC) using HPLC compatible with different detectors: FLD or UV and ESI-MS/MS. An analytical method for derivatization of amino acids was developed for Kvass (Estonian soft drinks) as a demonstration. The results were compared with a commercially available reagent (6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate aka 6-AQC) which has been commonly employed in different applications for 30 years.
Larissa would like to thank the Estonian Education and Youth Board for the Dora+ short-term mobility scholarship. Ngan would like to thank the Chair of Analytical Chemistry for the financial support.
