Minireview on pKa values of bases in non-aqueous solvents

In a recent minireview, published in Eur. J. Org. Chem. an important part of our group’s acid-base chemistry research has been summarized: the pKa values of bases (pKaH values) determined over the years in acetonitrile have now been rigorously united into a single scale, whereby all the involved ΔpKa values have been considered for deriving the absolute pKaH values of the bases involved. Altogether 279 basic compounds are included in the scale from all major groups of organic bases (amines, pyridines, imidazoles, anilines, amidines, guanidines, phosphazenes, etc) and are linked with altogether 682 ΔpKa measurements. The full scale can be downloaded by clicking on the picture on the left. The minireview also presents possibilities to predict the pKa values of bases in other media – namely water, DMSO and THF – on the basis of MeCN pKaH values. It is expected that this minireview will be a useful tool for future researchers who need pKa values of bases in nonaqueous solvents for planning their studies or for interpreting research results.  

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