We are glad to announce that the second edition of the online course LC-MS Method Validation is open for registration at the address https://sisu.ut.ee/lcms_method_validation/ !
The course will be offered as a Massive Open On-line Course (MOOC) during Nov 28, 2017 – Feb 09, 2018. This is the second edition of this MOOC and, differently from the last year’s edition, the number of participants is not limited this time. So, whoever is interested is welcome to register!
This is a practice-oriented on-line course on validation of analytical methods, specifically using liquid chromatography-mass spectrometry as technique, mostly (but not limited to) using the electrospray (ESI) ion source. The course introduces the main concepts and mathematical apparatus of validation, covers the most important method performance parameters and ways of estimating them. The course is largely based on the recently published two-part tutorial review:
- Tutorial review on validation of liquid chromatography–mass spectrometry methods: Part I. A. Kruve, R. Rebane, K. Kipper, M.-L. Oldekop, H. Evard, K. Herodes, P. Ravio, I. Leito. Anal. Chim. Acta 2015, 870, 29-44
- Tutorial review on validation of liquid chromatography–mass spectrometry methods: Part II. A. Kruve, R. Rebane, K. Kipper, M.-L. Oldekop, H. Evard, K. Herodes, P. Ravio, I. Leito. Anal. Chim. Acta 2015, 870, 8-28
The course contains lectures, practical exercises and numerous tests for self-testing. In spite of being introductory, the course intends to offer sufficient knowledge and skills for carrying out validation for most of the common LC-MS analyses in routine laboratory environment. The real-life analysis situations for which there are either examples or self-tests are for example pesticide analyses in fruits and vegetables, perfluororalkyl acids in water, antibiotics in blood serum, glyphosate and AMPA in surface water, etc. It is important to stress, that for successful validation experience (both in analytical chemistry as such and also specifically in validation) is crucial and this can be acquired only through practice.
The course is free of charge. Receiving digital certificate (in the case of successful completion) is also free of charge. Printed certificate (to be sent by post) is available for a fee of 60 EUR. Registration is possible until the start of the course. The course material is available from the above address all the time and can be used via web by anyone who wishes to improve the knowledge and skills in analytical method validation (especially when using LC-ESI-MS).
Mass spectrometry is currently probably the No 1 technique for determining trace-level components in complex (especially biomed-related) mixtures. The key issues in such applications are sample preparation, sample introduction to MS and ionization of components of interest (analytes). Big efforts are continually made to improve any of them.
In his recent development – Sponge spray – Max Hecht, an AMS graduate, now PhD student at UT attempts improvements in all of the above issues. The elegant approach proposed by Max utilizes a volumetric sampling device – a hydrophilic sponge, which after absorbing a predetermined amount of sample (e.g. blood or urine), can be directly used for sample introduction to MS and ionizing the analytes.
The seriousness of the work has been demonstrated by the fact that it was accepted for publication by Analytical Chemistry, the top journal in the field. The published article Sponge Spray – Reaching New Dimensions of Direct Sampling and Analysis by MS is now available from the journal website.
Further developments of this approach may lead e.g. to fast medical diagnosis MS methods that, contrary to the current situation with MS in medicine, could be applied as “bed-side” diagnosis tools in hospitals.
(Photo: Max Hecht working with the sponge spray ion source)
On September 11, 2017 the third master thesis defence session in the history of the EACH programme took place at Åbo Akademi University (AAU)! Ime Bassey Isua-Ikoh and Dimitar Jovanovski successfully defended their master’s theses.
Congratulations to both of you!
(Photo on the left (left to right): Ime, Johan Bobacka, Dimitar)
Although all EACH thesis defences have members from both universities where students studied as well as from associated partners, this defence was nevertheless special by the highly international jury – Johan Bobacka (AAU), Manuel Miró (University of Balearic islands, Spain), Teem Näykki (SYKE; Finland) and Ivari Kaljurand (UT; Estonia). 75% of the members (all except Johan) participated via Skype. The connection worked well (occasionally some members disconnected, but they managed to quickly reconnect again) and serious discussions were held with both students. It is important to add that both Ime and Dimitar have already secured jobs/positions for them.
(Photo on the right: Ime discussing with the Jury members)
Together with the defences in Uppsala and recent defence in Lyon this defence in Åbo concludes the theses of the first intake of EACH students. All EACH students of the first intake have now successfully defended their theses!
This week was the first study week for the new students of Applied Measurement Science and EACH Erasmus Mundus Joint Programme. Altogether 23 students started their studies. The countries of origin of the students are Vietnam, Philippines, Hungary, Serbia, Nepal, China, Hong Kong, Georgia, Romania, Mexico, Indonesia, Venezuela, Pakistan and Turkey. During the introductory meeting an overview of the programme was given (see the slides) and a large number of questions were asked and answered, accompanied by tea/coffee and cake.
We wish successful studies to all new students!
On September 7, 2017 the second master thesis defence session in the history of the EACH programme took place at University Claude Bernard Lyon 1 (UCBL)! Aleksandra Lelevic, Gaurav Bhardwaj, Huian Liu, Marko Jovanovic, Oleksandra Burakhovska, Olivier Etebe Nonga, Rudolf Aro and Tetiana Melnyk successfully defended their master’s theses.
Congratulations to all of you!
The topics of the theses embraced a wide area of modern analytical problems (top-down LC-MS proteomics, industrial process control with gas chromatography and Raman spectrometry, accurate moisture measurement in solids, FT-IR analysis of plasticizers in concrete, etc). The majority of the theses were performed in collaboration with industry. This choice of topics and the long-standing industrial collaboration is rooted in the world-famous industrial analysis and control study direction at UCBL led by prof. Jérôme Randon.
At a small cosy drink after the defence students shared their memories of the study period in Lyon. The students were generally very happy about their study track. They praised especially the long and serious placement in industry, which taught them a wide range of useful skills and enabled establishing many contacts. Students also spoke about their future plans. Several of them have already secured jobs/positions.
On photo from the left: Marko, Jerome (academic coordinator at Lyon), Oleksandra, Olivier, Huian, Aleksandra, Rudolf, Gaurav (Tetiana unfortunately had to leave earlier).